Developmental Biology

Murine Homeobox Gene Control of Embryonic Patterning and - download pdf or read online

By Thomas Lufkin

ISBN-10: 0444514988

ISBN-13: 9780444514981

the 1st homeobox gene used to be molecular cloned approximately 20 years in the past, and because that point great growth has been made in our figuring out of the distribution of homeobox genes within the genomes of many animal species and the typical practical function the encoded homeodomains play in cell-type specification, morphogenesis and development.

The amino acid series of the homeodomain, in addition to the presence of different conserved protein domain names, has allowed the category of homeodomain-containing proteins (homeoproteins) into over thirty separate households (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). in lots of circumstances a unmarried gene has been proven to totally direct the morphogenesis and improvement of a fancy tissue, organ or perhaps a complete physique phase. but how this "master" regulatory skill of homeoproteins services on the molecular point to a wide measure nonetheless continues to be a secret, partly as a result of our restricted figuring out of the character of either homeoprotein transcriptional cofactors or even extra elusively, the downstream goals of homeoprotein functionality.

In the stories offered right here it really is restricted basically to what has been realized in vertebrate structures, largely concentrating on the mouse, due to the strengths of the technical techniques at present current in murine developmental genetics that aren't but to be had to an analogous measure in different vertebrate species. regardless of this mammalian predilection, a standard thread to every of those studies is the underlying value of what has been realized approximately homeoprotein functionality in different animal species, rather arthropods like Drosophila.

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Murine Homeobox Gene Control of Embryonic Patterning and Organogenesis (Advances in Developmental Biology) by Thomas Lufkin

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