By Thomas Lufkin
The amino acid series of the homeodomain, in addition to the presence of different conserved protein domain names, has allowed the category of homeodomain-containing proteins (homeoproteins) into over thirty separate households (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). in lots of circumstances a unmarried gene has been proven to totally direct the morphogenesis and improvement of a fancy tissue, organ or perhaps a complete physique phase. but how this "master" regulatory skill of homeoproteins services on the molecular point to a wide measure nonetheless continues to be a secret, partly as a result of our restricted figuring out of the character of either homeoprotein transcriptional cofactors or even extra elusively, the downstream goals of homeoprotein functionality.
In the stories offered right here it really is restricted basically to what has been realized in vertebrate structures, largely concentrating on the mouse, due to the strengths of the technical techniques at present current in murine developmental genetics that aren't but to be had to an analogous measure in different vertebrate species. regardless of this mammalian predilection, a standard thread to every of those studies is the underlying value of what has been realized approximately homeoprotein functionality in different animal species, rather arthropods like Drosophila.
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Murine Homeobox Gene Control of Embryonic Patterning and Organogenesis (Advances in Developmental Biology) by Thomas Lufkin